May 19, 2024 · WebSep 6, 2024 · Thiotepa is a cytotoxic anticancer drug and as with other potentially toxic compounds, caution should be exercised in handling and preparation of thiotepa. Preparation of Solution: 1 Thiotepa for injection should be reconstituted with 1.5 mL of Sterile Water for Injection resulting in a drug concentration of approximately 10 mg/mL.
Thiotepa - Pharmaceutical Drugs - NCBI Bookshelf
WebApr 25, 2024 · It is supplied as a non-pyrogenic, sterile Iyophilized powder for intravenous, intracavitary or intravesical administration, containing 15 mg of thiotepa. Thiotepa for injection is a synthetic product with antitumor activity. The chemical name for thiotepa is Aziridine, 1,1’1”-phosphinothioylidynetris-, or Tris (1-aziridinyl) phosphine sulfide. WebJan 4, 2024 · Thiotepa is a cytotoxic agent of the polyfunctional type, related chemically and pharmacologically to nitrogen mustard. The radiomimetic action of thiotepa is believed to occur through the release of ethylenimine radicals which, like irradiation, disrupt the bonds of DNA. One of the principal bond disruptions is initiated by alkylation of ... plural form of buoy
tespa, Thioplex (thiotepa) dosing, indications, interactions, …
WebFind the best THIOTEPA or TEPADINA prices near you now with our cost comparison tool and start saving today. ... DISCOUNT ONLY - NOT INSURANCE. Discounts are available … Web2.2. Use. Thiotepa is a cytostatic agent. It has been used in the treatment of lymphomas and a variety of solid tumours, such as those of breast and ovary; it has also been used in cases of urinary bladder malignancies, meningeal carcinomatosis and various soft-tissue tumours (Wright et al., 1958; Hollister & Coleman, 1980; Hagen et al., 1987; Reynolds, 1989). WebThiotepa (N,N′,N″-triethylenethiophosphoramide, MW 189) is an older chemotherapeutic anticancer agent that acts by alkylating DNA and is prescribed for treating solid tumors and various leukemias often at high doses and in combination with other anticancer agents. Mass spectrometric methods were developed for characterizing the structure of thiotepa … plural form of calf