WebFeb 17, 2024 · The rate of intravenous phenytoin administration should not exceed 50 mg/minute in adults and 1 to 3 mg/kg/minute (or 50 mg/minute, whichever is slower) in pediatric patients because of the risk of severe hypotension and cardiac arrhythmias. Careful cardiac monitoring is needed during and after administering intravenous phenytoin. Webin phenytoin pharmacokinetics and/or efficacy and toxicity. Furthermore, phenytoin demonstrates non-linear pharmacokinetics even within the therapeutic range. The enzyme system involved in phenytoin metabolism gradually becomes saturated, resulting in a decrease in the rate of elimination of phenytoin as the dose is increased4. This means
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