WebBackground/Purpose: Filgotinib (FIL) is a potent oral selective janus kinase 1 inhibitor which is currently being investigated as an agent to treat rheumatoid arthritis (RA). In the FINCH 1 study (NCT02889796), FIL in combination with methotrexate (MTX) provided a rapid and meaningful clinical response in patients with inadequate response to MTX. … WebJul 23, 2024 · Conclusions and relevance: Among patients with active RA who had an inadequate response or intolerance to 1 or more bDMARDs, filgotinib, 100 mg daily or …
Filgotinib Improved Work Productivity and Activity Impairment in ...
WebMay 29, 2024 · FINCH 1 is an ongoing, randomized, double-blind, placebo- and active-controlled Phase 3 study evaluating filgotinib versus adalimumab or placebo in adults with moderately-to-severely active rheumatoid arthritis on a stable background dose of methotrexate but with a prior inadequate response to methotrexate. WebFeb 28, 2024 · Objectives: Evaluate the efficacy and safety of the Janus kinase-1 inhibitor filgotinib in Japanese patients with rheumatoid arthritis (RA) and inadequate response to methotrexate (MTX). Methods: Data from 147 Japanese patients in FINCH 1, a 52-week global Phase 3 study, were analysed up to 24 weeks. Patients received once-daily … la from inglewood
Filgotinib Improved Work Productivity and Activity Impairment in ...
WebJun 15, 2024 · Die aktuellen Leitlinien sehen in der Therapie der rheumatoiden Arthritis bei Versagen konventioneller, synthetischer DMARDs eine Therapieeskalation auf ein Biologikum oder einen JAK-Inhibitor vor. Die Frage, welcher Substanzklasse oder welchem konkreten Medikament der Vorzug zu geben ist, lässt sich jedoch nicht evidenzbasiert … WebFeb 25, 2024 · This FINCH 1 study evaluates the efficacy and safety of filgotinib versus placebo or adalimumab therapy in patients with active RA, regardless of ongoing … WebJul 1, 2024 · The FINCH 1 study assessed filgotinib, an oral JAK-1-preferential inhibitor, to address the unmet needs for RA treatment in MTX-IR patients. Two doses of filgotinib … la fromagerie bloomsbury menu