Webeton were identified as critical determinants of CTGF expression induced by LPA and 5-HT, and also by TGF-b. Connective tissue growth factor (CTGF)1 belongs to the fam-ily of low affinity insulin-like growth factor binding proteins, which consists of Mac25, the nov oncogenes, and cyr61 (1), and is also classified as a member of the CCN (CYR61 ... WebThe LPA-induced YAP activation is supported by the increased CTGF and CYR61 transcription (Supplemental Fig. S6A). We also found that LPA increased LATS2 expression, which temporally followed YAP dephosphorylation ( Fig. 6 B,C), suggesting that YAP activation induces LATS2 expression upon LPA stimulation.
CREB-dependent LPA-induced signaling initiates a pro-fibrotic …
WebMar 27, 2015 · The graphs summarize quantification of multiple experiments with LPA-stimulated cells set to 1 in each experiment: cellular CTGF: n = 2 ± half range; secreted CTGF control: n = 3, secreted CTGF LPA … WebTogether with its downstream mediator CTGF (connective tissue growth factor), TGF-β1 stimulates production of collagen and extracellular matrix and causes thickening of the GBM, resulting in podocyte detachment and apoptosis. ... Autotaxin is the enzyme that generates LPA and this molecule has potent pro-fibrotic effects to induce epithelial ... csharp xmldocument remove namespaces
Induction of Connective Tissue Growth Factor by …
WebDec 6, 2007 · Connective tissue growth factor (CTGF) seems to be involved in the fibrotic response. Several muscular dystrophies are characterized by a progressive weakness and wasting of the musculature, and by extensive fibrosis. However, the exact role of CTGF in skeletal muscle is unknown. ... (TGF-β) and lysophosphatidic acid (LPA). CTGF induced ... WebActivation of LPA1 on mesothelial cells induced these cells to express connective tissue growth factor (CTGF), driving fibroblast proliferation in a paracrine fashion. ... therefore … WebMar 27, 2015 · The graphs summarize quantification of multiple experiments with LPA-stimulated cells set to 1 in each experiment: cellular CTGF: n = 2 ± half range; secreted … csharp xml comments